Markers of exposure to carcinogens.

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Markers of exposure to carcinogens.

Methods have been developed for the detection of exposure to carcinogens and other DNA damaging agents in experimental animals and man through the detection of carcinogens or their metabolic derivatives in body fluids, or through adducts bound covalently to DNA or hemoglobin. The successful use of urinary markers of genotoxic exposures has been reported with respect to nitrosoproline as an indi...

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Monitoring human exposure to 2-hydroxyethylating carcinogens.

It is known that human hemoglobin contains low levels of N-terminal N-(2-hydroxyethyl)valine. Possible sources of this modified amino acid are exposure to ethylene oxide or other 2-hydroxy-ethylating agents. Although such processes are likely to occur endogenously, the exogenous contribution to the adduct formation is unclear. In order to explore the latter, we have analyzed N-(2-hydroxyethyl)v...

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Environmental exposure to carcinogens in northwestern Cameroon.

BACKGROUND In developing countries, 6% of deaths are due to cancer but cancer prevention is not practiced. Humans can prevent themselves from a number of workplace and environmental carcinogens. OBJECTIVES To assess exposure to carcinogens, risky behaviours and associated preventive methods. METHODS A structured questionnaire was used to collect information on carcinogen exposure in the wor...

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Reducing occupational exposure to chemical carcinogens.

Strategies for controlling occupational exposure to chemical carcinogens are set out in the European Union Carcinogens Directive and in national legislation such as the British Control of Substances Hazardous to Health Regulations. While such legislative requirements must apply to all occupational chemical carcinogens, it is argued that priority should be given to controlling those agents that ...

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Exposure to occupational carcinogens in great britain.

INTRODUCTION This paper describes the available exposure information for carcinogens in Great Britain and discusses some of the issues involved in using such data to inform an assessment of the attributable occupational cancer burden. METHODS Carcinogenic agents or occupations/industries such as hairdressers were identified from the list of International Agency for Research on Cancer groups 1...

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ژورنال

عنوان ژورنال: Environmental Health Perspectives

سال: 1989

ISSN: 0091-6765,1552-9924

DOI: 10.1289/ehp.89819